![]() ![]() Mishra, “Biopharmaceutical classification system: A strategic tool for oral drug delivery technology,” Asian J. Loudos, “Molecular Nanomedicine Towards Cancer?:,” J. Amidon, “Solubilization and dissolution of insoluble weak acid, ketoprofen: Effects of pH combined with surfactant,” Eur. Mazumder, “Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol,” Saudi Pharm. Radhakrishnan, “Novel approaches in the preparation of solid dispersion on solubility: A review,” Int. ![]() Lingala, “Solubility enhancement techniques,” Int. Savjani, “Drug Solubility: Importance and Enhancement Techniques,” ISRN Pharm., vol. Nekkanti, “Insoluble drug delivery strategies?: review of recent advances and business prospects,” Acta Pharm. The ketoprofen formula with surfactant concentration of 60% (F3) showed the highest dissolution rate compared to (F1) and (F2) as well as with comparators. Statistical analysis using a completely randomized design showed a significant difference between dissolution rates (F1), (F2) and (F3) with comparators. The dissolution test results showed that the ketoprofen formulated by the SEDDS method could increase the dissolution rate of ketoprofen, the dissolution percentage of each formula after 1 hour was 62.91% (F1), 78.09% (F2), 100.6% (F3), and 49.95% comparison. Three formulas were made containing the active ingredient ketoprofen 50 mg, Tween 80: span 80 (3: 1) as a surfactant with a concentration of 30% (F1), 45% (F2), 60% (F3) and oil as a carrier. Ketoprofen solubility tests were carried out on several types of oil and surfactants, namely corn oil, sunflower oil, soybean oil, oleic acid, tween 80 and span 80 using the method saturation solubility. Therefore, to increase the dissolution rate, a ketoprofen formulation was carried out using the SEDDS method. ![]() Self-Emulsifying Drug Delivery System (SEDDS) can improve the bioavailability of drugs that have low solubility with high permeability. Based on the classification Biopharmaceutical Classification System (BCS), ketoprofen is included in class II, which has low solubility with good permeability characteristics (effective permeability in humans for ketoprofen 8.70x10 -4 cm / s). ![]() AbstractĪfter oral administration of the drug, drug dissolution is a requirement for absorption of a drug into the systemic circulation. Faculty of Pharmacy, Universitas Hasanuddinĭissolution, ketoprofen, Self-emulsifyng Drug Delivery System (SEDDS). ![]()
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